- April 12, 2022
Zolmitriptan is a selective 5-hydroxytryptamine 1B/1D (5-HT 1B/1D) receptor agonist. Zolmitriptan binds with high affinity to human recombinant 5-HT 1D and 5-HT 1B receptors. The therapeutic activity of zolmitriptan for the treatment of migraine headaches can most likely be attributed to the agonist effects at the 5-HT 1B/1D receptors on intracranial blood vessels. Zolmitriptan is well absorbed after oral administration and well tolerated.