- April 12, 2022
Lioraz (Baclofen) is a muscle relaxant derived from 8-Amino-butyric acid. Baclofen possesses pharmacological properties which distinguish it from all other known muscle relaxants. Baclofen is rapidly and almost completely absorbed from the gastro-intestinal tract following an oral dose. The peak plasma concentration occurs 1 to 3 hours following ingestion. It crosses the blood-brain barrier with a concentration in cerebrospinal fluid (CSF) corresponding to about 12% of those in the plasma. About 70% to 80% of a dose is excreted in the urine mainly as unchanged drug. The elimination half-life of Baclofen is about 3 to 4 hours in plasma and about 5 hours in the CSF.
Lioraz interferes with the release of excitatory neurotransmitters and inhibits monosynaptic and polysynaptic transmission at the spinal level and polysynaptic reflex at the spinal level. Lioraz has a beneficial action on the involuntary muscle contractions, so it markedly reduces these contractions and improves the patient’s mobility, and makes it easier for him to manage without aid, while at the same time also facilitating passive and active physiotherapy.